20 weeks of supplementation with BioSil (ch-OSA) helped return skin to a more youthful state with shallower wrinkles, resulting in a clinically significant improvement in skin texture and resilience.
Supplementation with M-OSA and MMST for 150 days, provide betterment on facial wrinkles and UV spots and decrease of hair aluminium levels
Silicon supplementation stimulates COL-1 and osteocalcin synthesis in human osteoblast-like cells through the BMP-2/Smad1/5/RUNX2 signaling pathway
Oral intake of ch-OSA® showed significant beneficial effects on the health of hair, skin and nails with good tolerability.
The incorporation of orthosilicic acid (Si(OH)4), the form of silicon in the body, within collagen scaffolds was demonstrated as an in vitro platform to study silicates and identify key genes affected by silicates.
Orthosilicic acid is suggested to have a beneficial role in the hair, leading to a faster growth rate and an increase in resistance to aggression.
A reduction in both cell metabolism and proliferation of keratinocytes and macrophages supports the empirical clinical benefits of this natural mineral water (NMW) in hyperkeratotic conditions, such as psoriasis and atopic dermatitis.
Ortho-silicic acid (H4SiO4) might be a prominent therapeutic agent in humans, on bone formation and bone density, Alzheimer disease, immunodeficiency, skin, hair, and nails condition, as well as on tumour growth.
Rice bran ash extract (RBE) could be used as a novel material to promote melanin synthesis by stimulating melanocytes with its soluble Si and mineral components.
9 months supplementation with ch-OSA demonstrated a positive effect on tensile strength including elasticity and break load and resulted in thicker hair.
According to reported studies, among the different chemical forms available, the orthosilicic acid (OSA) presents the higher bioavailability, whereas the others forms have absorption inversely proportional to the degree of polymerization.
Orthosilicic acid (OSA) at physiological concentrations stimulates collagen type 1 synthesis in human osteoblast-like cells and enhances osteoblastic differentiation.
Dietary silicon intake is correlated positively and significantly with bone mineral density (BMD) at all hip sites in men and premenopausal women.
ch-OSA® has shown to have synergistic effects with calcium and Vitamin D, indicating its potential role in the management of osteoporosis.
Accumulated evidence over the last 30 years suggests that dietary silicon as an important role in bone formation and bone and connective tissue health.
Human exposure to aluminium has been identified as a possible contributor to multiple sclerosis (MS). Regular drinking of a silicon-rich mineral water up to 1.5L daily for 12 weeks increased the urinary excretion of aluminium significantly. The majority of individuals, 14 out of 15, excreted more aluminium in their urine relative to the baseline period.
Drinking up to 1L of a silicon-rich mineral water each day for 12 weeks showed a statistically reduction in body burden of aluminium in individuals with Alzheimer’s disease. Cognitive performance showed clinically relevant improvements in at least 3 out of 15 individuals.
This in vitro study highlighted the importance of rice husk silica liquid (RHSL) on Type 2 Diabetes Mellitus (T2DM) protection. It demonstrated that RHSL reversed the reactive oxidative species (ROS) production and alleviated streptozotocin (STZ)-induced apoptosis by inducing autophagy in RIN-m5F pancreatic β cells.
This animal study demonstrated that rice-husk silica liquid (RHSL) ameliorated streptozotocin (STZ)-induced insulin resistance and liver tissue damage in diabetic model of C57BL/6J mice.
This preclinical study showed the beneficial effects of silicon-containing water (BT) on gastrointestinal function and gut microbiota, which demonstrated the therapeutic potential of BT for the prevention or treatment of gastrointestinal disorders.