The incorporation of orthosilicic acid (Si(OH)4), the form of silicon in the body, within collagen scaffolds was demonstrated as an in vitro platform to study silicates and identify key genes affected by silicates.
A reduction in both cell metabolism and proliferation of keratinocytes and macrophages supports the empirical clinical benefits of this natural mineral water (NMW) in hyperkeratotic conditions, such as psoriasis and atopic dermatitis.
Ortho-silicic acid (H4SiO4) might be a prominent therapeutic agent in humans, on bone formation and bone density, Alzheimer disease, immunodeficiency, skin, hair, and nails condition, as well as on tumour growth.
According to reported studies, among the different chemical forms available, the orthosilicic acid (OSA) presents the higher bioavailability, whereas the others forms have absorption inversely proportional to the degree of polymerization.
Human exposure to aluminium has been identified as a possible contributor to multiple sclerosis (MS). Regular drinking of a silicon-rich mineral water up to 1.5L daily for 12 weeks increased the urinary excretion of aluminium significantly. The majority of individuals, 14 out of 15, excreted more aluminium in their urine relative to the baseline period.
Drinking up to 1L of a silicon-rich mineral water each day for 12 weeks showed a statistically reduction in body burden of aluminium in individuals with Alzheimer’s disease. Cognitive performance showed clinically relevant improvements in at least 3 out of 15 individuals.
This in vitro study highlighted the importance of rice husk silica liquid (RHSL) on Type 2 Diabetes Mellitus (T2DM) protection. It demonstrated that RHSL reversed the reactive oxidative species (ROS) production and alleviated streptozotocin (STZ)-induced apoptosis by inducing autophagy in RIN-m5F pancreatic β cells.
This preclinical study showed the beneficial effects of silicon-containing water (BT) on gastrointestinal function and gut microbiota, which demonstrated the therapeutic potential of BT for the prevention or treatment of gastrointestinal disorders.